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Thank you for posting your query in Microsoft Community.
- Did you make any changes prior to this issue?
- Does this happen only with Microsoft Edge?
- Did you check with other browser?
I suggest you to follow the below methods and check if it helps.
Method 1:
Try to run the blocked program using the command prompt. Open elevated command prompt (Command Prompt as Administrator).
To open Command Prompt as Administrator, press Windows key + X and select Command Prompt (Admin).
To open the command prompt go to c:/windows/system32, right click on cmd.exe and select Run as Administrator.
In the command prompt, go to the directory where your file has been located. For example, if you have it in the download folder, type cd/user/your username/downloads and hit enter.
Next, enter the name of the file that you want to run and hit enter. This should allow you to run the program without any error.
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If the issue persist, follow the below method and check.
Method 2:
You can also try to unblock your file from the properties. Right-click on the installation file on which you are getting the Publisher has been blocked from running software on your computer error and select Properties. At the bottom of the properties window, click “Unblock”.
Now try running the file again, and you should be able to fix this error.
Hope the information helps, if you have any further queries, feel free to post. We are here to assist you. Regards,